Welcome to the distribution site for Electrophysiology of the Neuron (EOTN). This software simulates the electrophysiological behavior of single neurons. The 2014a version of EOTN is based on a program of the same name originally published by John Huguenard and David McCormick. We have updated the program to include versions for Microsoft Windows and Mac OSX and we have enhanced the user 
interface, while keeping all functionality of the original program intact. The EOTN package contains two simulators: SimCC runs "current-clamp" simulations and SimVC simulates "voltage-clamp" experiments.
This updated version of EOTN was developed as an active learning tool in the undergraduate course Introduction to Neurobiology taught by Dr. Michael Markham at the University of Oklahoma. You are welcome to download and use the simulation assignments designed for this class.
Program Download
To download the installation file you will need to first complete this very brief anonymous survey that will give us information about where and how the program is being used. We will use this information only to improve the program in future releases and monitor usage patterns. After completing the survey, you will be taken to the download page. To install the program once you have downloaded the appropriate installation file:
- Windows version: Download the EOTN setup file (3.5 MB) then navigate to the location of the downloaded file and run it. The installation is self-explanatory from there. When using EOTN for Windows, follow these steps when downloading and running simulation files from online sources.
- MacOS version: Download the EOTN setup file then run this setup file to install the software. The programs will be installed in your Applications folder. It may be necessary to follow these instructions to temporarily change your security settings so that you can install the software. When using the MacOS version of EOTN you will also need to follow these steps when downloading and running simulation files from online sources.
If you encounter a problem with the programs or have suggestions for improvement, please fill out and submit this brief anonymous form.
Financial Support
Development of this software was supported in part by an Ed Cline Faculty Development Award from the Faculty Senate of the University of Oklahoma and by the Case–Hooper endowment funded through
a gift from Dr. and Mrs. Robert Case to The University of Oklahoma. This material is also based upon work supported by the National Science Foundation under Grant Numbers 1257580 and 1350753.